Language Modeling by Clustering with Word Embeddings for Text Readability Assessment

We present a clustering-based language model using word embeddings for text readability prediction. Presumably, an Euclidean semantic space hypothesis holds true for word embeddings whose training is done by observing word co-occurrences. We argue that clustering with word embeddings in the metric space should yield feature representations in a higher semantic space appropriate for text regression. Also, by representing features in terms of histograms, our approach can naturally address documents of varying lengths. An empirical evaluation using the Common Core Standards corpus reveals that the features formed on our clustering-based language model significantly improve the previously known results for the same corpus in readability prediction. We also evaluate the task of sentence matching based on semantic relatedness using the Wiki-SimpleWiki corpus and find that our features lead to superior matching performance

Superior Facial Expression, But Not Identity Recognition, in Mirror-Touch Synesthesia

Simulation models of expression recognition contend that to understand another's facial expressions, individuals map the perceived expression onto the same sensorimotor representations that are active during the experience of the perceived emotion. To investigate this view, the present study examines facial expression and identity recognition abilities in a rare group of participants who show facilitated sensorimotor simulation (mirror-touch synesthetes). Mirror-touch synesthetes experience touch on their own body when observing touch to another person. These experiences have been linked to heightened sensorimotor simulation in the shared-touch network (brain regions active during the passive observation and experience of touch). Mirror-touch synesthetes outperformed nonsynesthetic participants on measures of facial expression recognition, but not on control measures of face memory or facial identity perception. These findings imply a role for sensorimotor simulation processes in the recognition of facial affect, but not facial identity

El cine como recurso pedagógico en el aprendizaje significativo en los estudiantes de la Universidad Científica del Sur, 2017 - 2

La presente investigación es acerca de la posibilidad de utilizar el cine como un recurso pedagógico con miras a lograr un entorno de aprendizaje significativo, en los estudiantes del curso de Marketing Global de la Facultad de Gestión Empresarial de la Universidad Científica del Sur, 2017-2. Corresponde a una investigación con enfoque cuantitativo de alcance descriptivo y diseño preexperimental, con una muestra no probabilística, intencional. Las técnicas aplicadas fueron la observación y el análisis documental, empleando como instrumentos la lista de cotejo con escala de Likert. Los resultados obtenidos permitieron explicar los hechos o fenómenos que influyeron en el desarrollo del proceso de aprendizaje significativo en base a un currículo por competencias. Se concluyó comprobando que la aplicación del cine como recurso pedagógico incide de forma altamente positiva en el aprendizaje significativo de los estudiantes del curso de Marketing Global de la Universidad Científica del Sur, 2017-2.Trabajo de investigaciónCampus Lima Centr

MOZ-mediated repression of p16(INK) (4) (a) is critical for the self-renewal of neural and hematopoietic stem cells

Although inhibition of p16(INK4a) expression is critical to preserve the proliferative capacity of stem cells, the molecular mechanisms responsible for silencing p16(INK4a) expression remain poorly characterized. Here, we show that the histone acetyltransferase (HAT) monocytic leukemia zinc finger protein (MOZ) controls the proliferation of both hematopoietic and neural stem cells by modulating the transcriptional repression of p16(INK4a) . In the absence of the HAT activity of MOZ, expression of p16(INK4a) is upregulated in progenitor and stem cells, inducing an early entrance into replicative senescence. Genetic deletion of p16(INK4a) reverses the proliferative defect in both Moz(HAT) (-) (/) (-) hematopoietic and neural progenitors. Our results suggest a critical requirement for MOZ HAT activity to silence p16(INK4a) expression and to protect stem cells from early entrance into replicative senescence

Expression of the MOZ-TIF2 oncoprotein in mice represses senescence

The MOZ-TIF2 translocation, which fuses monocytic leukemia zinc finger protein (MOZ) histone acetyltransferase (HAT) with the nuclear co-activator TIF2, is associated with the development of acute myeloid leukemia. We recently found that in the absence of MOZ HAT activity, p16INK4a transcriptional levels are significantly increased, triggering an early entrance into replicative senescence. Because oncogenic fusion proteins must bypass cellular safeguard mechanisms, such as senescence and apoptosis, to induce leukemia, we hypothesized that this repressive activity of MOZ over p16INK4a transcription could be preserved, or even reinforced, in MOZ leukemogenic fusion proteins, such as MOZ-TIF2. We describe here that, indeed, MOZ-TIF2 silences expression of the CDKN2A locus (p16INK4a and p19ARF), inhibits the triggering of senescence and enhances proliferation, providing conditions favorable to the development of leukemia. Furthermore, we describe that abolishing the MOZ HAT activity of the fusion protein leads to a significant increase in expression of the CDKN2A locus and the number of hematopoietic progenitors undergoing senescence. Finally, we report that inhibition of senescence by MOZ-TIF2 is associated with increased apoptosis, suggesting a role for the fusion protein in p53 apoptosis-versus-senescence balance. Our results underscore the importance of the HAT activity of MOZ, preserved in the fusion protein, for repression of the CDKN2A locus transcription and the subsequent block of senescence, a necessary step for the survival of leukemic cells.Work in our laboratory is supported by the Leukemia and Lymphoma Research Foundation (LLR), Cancer Research UK (CRUK), and the Biotechnology and Biological Sciences Research Council (BBSRC)

Developing an e-infrastructure for social science

We outline the aims and progress to date of the National Centre for e-Social Science e-Infrastructure project. We examine the challenges faced by the project, namely in ensuring outputs are appropriate to social scientists, managing the transition from research projects to service and embedding software and data within a wider infrastructural framework. We also provide pointers to related work where issues which have ramifications for this and similar initiatives are being addressed

Posicionamiento de marca del hospedaje Canchis en el distrito Pomacanchi en la provincia de Acomayo, Cusco 2022

De acuerdo al trabajo de investigación cuyo título es “Posicionamiento de marca del hospedaje Canchis en el distrito Pomacanchi en la provincia de Acomayo, Cusco 2022” que se identificó y desarrollo el objetivo general describir el posicionamiento de marca del hospedaje Canchis en el distrito Pomacanchi en la provincia de Acomayo, Cusco 2022; es así que metodológicamente la investigación fue de tipo básica, con enfoque cuantitativo, de diseño no experimental, con alcance descriptivo-transversal. Con una población de 1920 huéspedes del distrito de Pomacanchi obtenida dicha cantidad según el registro de huéspedes en el 2021, y como tipo de muestreo fue de tipo probabilístico teniendo un resultado de acuerdo a la fórmula para muestras finitas de 321 huéspedes. Procesada y analizada la información recogida de la muestra a través de la encuesta se concluyó que en relación a la variable posicionamiento de marca el 41.5% se considera como inadecuado, el 27.6% regular y el 30.9% siendo adecuado, considerando que el posicionamiento de marca del hospedaje no logra tener un impacto en la mente de la población y como recomendación para poder solucionar este problema es desarrollar un plan de marca, estableciendo estrategias como el uso de la tecnología para que el hospedaje pueda hacerse conocido en la Canchis y posteriormente en la región del Cusco.According to the research work whose title is "Brand positioning of the Canchis lodging in the Pomacanchi district in the province of Acomayo, Cusco 2022" that the general objective was identified and developed to describe the brand positioning of the Canchis lodging in the Pomacanchi district in the province of Acomayo, Cusco 2022; Thus, methodologically, the research was of a basic type, with a quantitative approach, of a non-experimental design, with a descriptive-transversal scope. With a population of 1920 guests from the Pomacanchi district, said amount was obtained according to the guest registry in 2021, and as a type of sampling it was probabilistic, having a result according to the formula for finite samples of 321 guests. After processing and analyzing the information collected from the sample through the survey, it was concluded that in relation to the brand positioning variable, 41.5% are considered inadequate, 27.6% regular, and 30.9% being adequate, considering that brand positioning of the lodging does not manage to have an impact on the minds of the population and as a recommendation to be able to solve this problem is to develop a brand plan, establishing strategies such as the use of technology so that the lodging can become known in the Canchis and later in the Cusco region.Mercadotecni

Patterns in Deep Time

In this paper, we explore how textile pattern-making can be a useful activity for live coders used to manipulating software. We ran an algorithmic patterns workshop in July 2022 -- with a node at "on the fly" festival in Barcelona, a node in Sheffield and the workshop leader in Penryn -- where we created an activity recreating ancient patterns by weaving on tablet looms that we constructed from card and yarn, and sent to the participants for this remote, multi location workshop. One of the aims of the Algorithmic Pattern project is to highlight the relationship people have had with patterns over history, and how we can use this to uncover certain misconceptions we have about algorithmic patterns in contemporary society. We collected responses from those who participated in the workshop and collated the responses. We found that tablet weaving allows us to connect the physical patterns with their algorithmic descriptions. Also, errors relate with the trade-off among expectations and surprise and exploring new unexpected possibilities. Finally, sharing the experiences among the participants allows us to observe how we interpret patterns when comparing it with other experiences